How to use the SureClick Autoinjector

Here are the main steps of using the SureClick Autoinjector.

Once you have been trained to administer Repatha®, please refer to the Patient Medication Information leaflet that comes with your Repatha® medication for step-by-step instructions and helpful illustrations.

Ask your doctor if you have any further questions on how to use Repatha®.

Summary of the main steps


Step 1: Prepare

  • Remove one SureClick Autoinjector from the package. Wait at least 30 minutes for the autoinjector to reach room temperature before injecting.
  • Inspect the SureClick Autoinjector to make sure the medicine in the window is clear and colourless to slightly yellow. Check the expiration date.
  • Gather all materials needed for your injection: alcohol wipes; cotton ball or gauze pad; adhesive bandage; sharps disposal container.
  • Prepare and clean your injection site with an alcohol wipe. Only use these injection sites: thigh, stomach area (abdomen), except for a two-inch area around the navel; outer area of upper arm (if someone else is giving the injection).


Step 2: Get ready

Pull the orange cap straight off when you are ready to inject.

  • Do not remove the orange cap from the autoinjector until you are ready to inject.
  • Do not leave the orange cap off for more than 5 minutes. This can dry out the medicine and may clog the needle when you take the injection.
  • Create a firm surface at the selected injection site (thigh, stomach, or outer area of the upper arm), by using either the Stretch Method or the Pinch Method.
    • Stretch the skin firmly by moving your thumb and fingers in opposite directions, creating an area about 2 inches (5 centimetres) wide.
    • Pinch the skin firmly between your thumb and fingers, creating an area about 2 inches (5 centimetres) wide. It is important to keep skin stretched or pinched while injecting.


Step 3: Inject

  • Keep holding the stretched or pinched skin. With the orange cap off, PUT the yellow safety guard on your skin at 90 degrees. The needle is inside the yellow safety guard. Do not touch the grey start button yet.
  • Firmly PUSH the autoinjector down onto your skin until it stops moving.
  • When you are ready to inject, PRESS the grey start button. You will hear a CLICK.
  • Keep PUSHING down on the skin. Then LIFT your thumb while still holding the autoinjector on the skin. Your injection could take about 15 seconds.
  • The window turns from clear to yellow when the injection is done. You may hear a second CLICK.
  • NOTE: After you remove the autoinjector from the skin, the needle will be automatically covered.

What will happen if I press the grey start button before I am ready to do the injection on my skin?

You can lift your thumb up off the grey start button and place the prefilled autoinjector back on your injection site. Then, you can push the grey start button again.

Can I release the grey start button after I start my injection?

You can release the grey start button, but continue to hold the autoinjector firmly against your skin during the injection.

Will the grey start button pop up after I release my thumb?

The grey start button may not pop up after you release your thumb if you held your thumb down during the injection. This is okay.

What do I do if I did not hear a second click?

If you did not hear a second click, you can confirm a complete injection by checking that the window has turned yellow.


Step 4: Finish

Discard the used autoinjector and orange needle cap in a sharps disposal container.

  • Examine the injection site. If there is blood, press (do not rub) a cotton ball or gauze pad on the injection site. Apply a bandage if needed.

Patient Support Program

HDL-C=high-density lipoprotein cholesterol; LDL-C=low-density lipoprotein cholesterol
Please note: Your Repatha® package may be different from that shown.

Do you have questions?

Connect with the Amgen Canada Medical Information team for help by phone at 1-866-502-6436 or email at