How to use the SureClick® Autoinjector

Here are the main steps of using the SureClick Autoinjector.

Once you have been trained to administer Repatha®, please refer to the Patient Medication Information leaflet that comes with your Repatha® medication for step-by-step instructions and helpful illustrations.

Ask your doctor if you have any further questions on how to use Repatha®.

Summary of the main steps


Step 1: Prepare

  • Remove one Repatha® SureClick Autoinjector from the package. Wait at least 30 minutes for the autoinjector to reach room temperature before injecting.
  • Inspect the Repatha® SureClick Autoinjector to make sure the medicine in the window is clear and colourless to slightly yellow. Check the expiration date.
  • Gather all materials needed for your injection: alcohol wipes; cotton ball or gauze pad; adhesive bandage; sharps disposal container.
  • Prepare and clean your injection site with an alcohol wipe. You can use: thigh, belly, except for a two-inch area around the navel; outer area of upper arm (if someone else is giving the injection).


Step 2: Get ready

  • Pull the orange cap straight off when you are ready to inject. Do not leave the orange cap off for more than 5 minutes. This can dry out the medicine and may clog the needle when you take the injection.
  • Stretch or pinch your injection site to create a firm surface.
    • Stretch skin firmly by moving your thumb and fingers in opposite directions, creating an area about 2 inches (5 centimetres) wide.
    • Pinch skin firmly between your thumb and fingers, creating an area about 2 inches (5 centimetres) wide.


Step 3: Inject

  • Hold the stretch or pinch. With the orange cap off, PLACE the autoinjector on your skin at 90 degrees.
  • Firmly PUSH the autoinjector down onto your skin until it stops moving.
  • When you are ready to inject, PRESS the grey start button. You will hear a CLICK.
  • Keep PUSHING down on your skin. Then LIFT your thumb. Your injection could take about 15 seconds.
  • NOTE: After you remove the autoinjector from your skin, the needle will be automatically covered.

What will happen if I press the grey start button before I am ready to do the injection on my skin?

You can lift your thumb up off the grey start button and place the prefilled autoinjector back on your injection site. Then, you can push the grey start button again.

Can I release the grey start button after I start my injection?

You can release the grey start button, but continue to hold the autoinjector firmly against your skin during the injection.

Will the grey start button pop up after I release my thumb?

The grey start button may not pop up after you release your thumb if you held your thumb down during the injection. This is okay.


Step 4: Finish

  • Discard the used autoinjector and orange needle cap in a sharps disposal container.
  • Examine the injection site. If there is blood, press (do not rub) a cotton ball or gauze pad on the injection site. Apply a bandage if needed.

Patient Support Program

  • Assistance accessing drug coverage
  • One-on-one Repatha® injection training with a nurse
  • Ongoing educational resources on Repatha® and cardiovascular health
  • Nurse support, ongoing personalized contact and treatment reminders