These resources provide valuable information on Repatha® and on cholesterol management that you can read on your own or discuss with your healthcare team.
Repatha® (evolocumab injection) is a medicine that helps to lower levels of cholesterol. Cholesterol is one of several fatty substances found in the bloodstream. Your total cholesterol is made up mainly of LDL cholesterol (LDL-C), often referred to as “bad” cholesterol, and HDL cholesterol (HDL-C), or “good” cholesterol.
LDL-C can build up in the walls of the arteries, forming plaque, which can lead to a narrowing of the arteries, slowing or blocking blood flow to vital organs such as the heart and brain. This can lead to a heart attack or stroke and could cause other health problems. HDL-C helps keep the bad cholesterol from building up in the arteries and protects against heart disease. Triglycerides, another type of fat found in the bloodstream, play an important role in the body but can increase the risk of heart disease if levels are too high.
Repatha® is used along with diet and in combination with usual therapy, including cholesterol-lowering medications called statins, to reduce the risk of heart attack, stroke and certain heart procedures (to restore blood flow to the heart) in adult patients who have cardiovascular disease.
Repatha® is also used alone or together with other cholesterol-lowering medicines, along with diet, in adults with primary hyperlipidemia (high cholesterol level in your blood) to reduce LDL-C.
You should stay on your cholesterol-lowering diet while taking Repatha®.
Evolocumab, the active ingredient of Repatha®, works by helping the liver’s ability to lower levels of total cholesterol, LDL-C and triglycerides in the blood. In addition, Repatha® raises levels of HDL-C.
Repatha® is given as an injection just under the skin (subcutaneous, or SC). You can take Repatha® every two weeks with the 140 mg/mL single-use prefilled SureClick® autoinjector, or once monthly with the 420 mg/mL Repatha® automated mini-doser.
It is important that you do not try to inject Repatha® until you have received training with a healthcare professional on how to properly use the SureClick autoinjector or the Repatha® automated mini-doser.
If your doctor has prescribed Repatha® along with a statin or other cholesterol-lowering medicine, follow your doctor’s instructions on how to take these medicines together.
Prevention of cardiovascular events and primary hyperlipidemia:
SureClick autoinjector: The usual dose for Repatha® is 140 mg every two weeks: one 1 mL prefilled SureClick autoinjector.
Repatha® automated mini-doser: The usual dose for Repatha® is 420 mg once monthly: one 3.5 mL prefilled cartridge with automated mini-doser.
Possible side effects include:
If you have a side effect that is not listed here or one that becomes bad enough to interfere with your daily activities, talk to your healthcare professional.
Learn more about the RepathaREADY® Support Program