Helpful Resources

These resources provide valuable information on Repatha® and on cholesterol management that you can read on your own or discuss with your healthcare team.

Frequently Asked Questions

What is Repatha?

Repatha® (evolocumab injection) is a medicine that helps to lower levels of cholesterol. Cholesterol is one of several fatty substances found in the bloodstream. Your total cholesterol is made up mainly of LDL cholesterol (LDL-C), often referred to as “bad” cholesterol, and HDL cholesterol (HDL-C), or “good” cholesterol.

LDL-C can build up in the walls of the arteries, forming plaque, which can lead to a narrowing of the arteries, slowing or blocking blood flow to vital organs such as the heart and brain. This can lead to a heart attack or stroke and could cause other health problems. HDL-C helps keep the bad cholesterol from building up in the arteries and protects against heart disease. Triglycerides, another type of fat found in the bloodstream, play an important role in the body but can increase the risk of heart disease if levels are too high.

Why have I been prescribed Repatha?

Repatha® is used along with diet and in combination with usual therapy, including cholesterol-lowering medications called statins, to reduce the risk of heart attack, stroke and certain heart procedures (to restore blood flow to the heart) in adult patients who have cardiovascular disease.

Repatha® is also used alone or together with other cholesterol-lowering medicines, along with diet, in adults with primary hyperlipidemia (high cholesterol level in your blood) to reduce LDL-C.

You should stay on your cholesterol-lowering diet while taking Repatha®.

How does Repatha Work?

Evolocumab, the active ingredient of Repatha®, works by helping the liver’s ability to lower levels of total cholesterol, LDL-C and triglycerides in the blood. In addition, Repatha® raises levels of HDL-C.

How do I take Repatha?

Repatha® is given as an injection just under the skin (subcutaneous, or SC). You can take Repatha® every two weeks with the 140 mg/mL single-use prefilled SureClick® autoinjector, or once monthly with the 420 mg/mL Repatha® automated mini-doser.

It is important that you do not try to inject Repatha® until you have received training with a healthcare professional on how to properly use the SureClick autoinjector or the Repatha® automated mini-doser.

If your doctor has prescribed Repatha® along with a statin or other cholesterol-lowering medicine, follow your doctor’s instructions on how to take these medicines together.

What is the usual dose of Repatha?

Prevention of cardiovascular events and primary hyperlipidemia:

SureClick autoinjector: The usual dose for Repatha® is 140 mg every two weeks: one 1 mL prefilled SureClick autoinjector.


Repatha® automated mini-doser: The usual dose for Repatha® is 420 mg once monthly: one 3.5 mL prefilled cartridge with automated mini-doser.

Does Repatha cause any side effects?

Possible side effects include:

  • Flu or flu-like symptoms (high temperature, sore throat, runny nose, cough and chills)
  • Common cold, such as runny nose, sore throat or sinus infections (nasopharyngitis or upper respiratory tract infections)
  • Nausea
  • Back pain
  • Joint pain (arthralgia)
  • High blood sugar levels (diabetes)
  • Injection site reactions (redness, bruising, pain, swelling or bleeding)
  • Allergic reactions including rash, hives, red itchy bumps on your skin (urticaria) and, in rare cases, swelling of face, mouth, tongue or throat (angioedema)

If you have a side effect that is not listed here or one that becomes bad enough to interfere with your daily activities, talk to your healthcare professional.

You are now leaving

Links to other sites are provided as a convenience to the viewer. Amgen Canada accepts no responsibility for the content of linked sites.

Patient Support Program

  • Assistance accessing drug coverage
  • One-on-one Repatha® injection training with a nurse
  • Ongoing educational resources on Repatha® and cardiovascular health
  • Nurse support, ongoing personalized contact and treatment reminders