How to take Repatha®

Repatha® is available in the following dosage forms


Single-Use Prefilled Sureclick Autoinjector

Repatha® can be given with the SureClick® Autoinjector. The recommended dose of Repatha® with the autoinjector is one injection (140 mg) every two weeks.


Repatha Automated Mini-Doser

Repatha® can also be given with the Repatha® automated mini-doser. The recommended dose of Repatha® with the mini-doser is one injection (420 mg) once monthly.

For the prevention of cardiovascular events and primary hyperlipidemia, including heterozygous familial hypercholesterolemia, the usual dose of Repatha® is 140 mg every 2 weeks or 420 mg once monthly.

For homozygous familial hypercholesterolemia, the usual dose of Repatha® is 420 mg, either once monthly or every two weeks. If you are on apheresis you may initiate treatment with 420 mg every 2 weeks to correspond with your apheresis schedule.

You and your doctor will have discussed your preferred method for taking Repatha®.

If your doctor decides that you or a caregiver can give you your Repatha® injections, you or your caregiver should receive training on the right way to prepare and inject Repatha®.

Do not try to inject Repatha® until you have been shown the right way by a healthcare professional, such as a doctor, nurse or pharmacist.

Always take Repatha® exactly as your doctor has told you. Check with your doctor if you are not sure.


How do I store Repatha®?

Store in a refrigerator at 2°C to 8°C in the original carton.

When removed from the refrigerator, Repatha® should be kept at controlled room temperature (up to 25°C) in the original carton and must be used within 30 days.

Protect Repatha® from direct light and do not expose to temperatures above 25°C. Do not freeze. Do not shake.

Keep Repatha® and all medicines out of the reach from children.

Do not throw away any medicines via wastewater or household waste. Ask your doctor or pharmacist how to throw away medicines you no longer use.


Continue with your cholesterol-lowering diet and current cholesterol-lowering medicine while taking Repatha®

Before starting Repatha®, you should be on a diet to lower your cholesterol. You should stay on this cholesterol-lowering diet while taking Repatha®.

If your doctor has prescribed Repatha® along with a statin or other cholesterol-lowering medicine, follow your doctor’s instructions on how to take these medicines together. In this case, please read the dosage instructions of the other medicines.

Patient Support Program

  • Assistance accessing drug coverage
  • One-on-one Repatha® injection training with a nurse
  • Ongoing educational resources on Repatha® and cardiovascular health
  • Nurse support, ongoing personalized contact and treatment reminders